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Natural Fermentation-Based Antioxidants & Anti-Aging Raw Materials

We produce high-purity Ergothioneine, Nervonic Acid, Ectoine, and PQQ using advanced synthetic biology fermentation. Our products are globally recognized for efficacy and safety, with regulatory approvals such as EFSA and GRAS for Ergothioneine, NHC standards for Nervonic Acid, EU and Japan approvals for Ectoine, and GRAS certification for PQQ. Our proprietary processes ensure top quality, regulatory compliance, and competitive pricing across dietary supplements,functional foods, pharmaceuticals, and cosmetics.

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Table of Contents

We understand the complexity of sourcing high-quality raw materials, so we have prepared detailed content for your convenience. This directory will help you quickly navigate to the sections most relevant to your needs.

Why Choose Us？

At Santa Biotech, we are committed to helping you deliver high-quality, science-backed products With cutting-edge synthetic biology fermentation technology, Santa Biotech offers you access to the latest advancements in functional ingredients like Ergothioneine, Nervonic Acid, Ectoine, and PQQ. Here’s why we’re the trusted choice for many B2B clients globally:
√ Certified Quality: ISO 22000 certified, meeting global safety and quality standards.
√ Advanced Production:Synthetic biology fermentation ensures purity, potency, and consistency while minimizing environmental impact.
√ Reliable Supply Chain: A strong supply network guarantees timely delivery and consistent quality.
√ Cost-Effective: Scalable production offers competitive pricing without sacrificing quality.
√ Regulatory Compliance: Our products meet international health, food, and cosmetic regulations.
√ Proven Efficacy: Scientifically tested to back your formulations.

Key Ingredients: Ergothioneine, Nervonic Acid, Ectoine, PQQ

Ergothioneine

Ergothioneine (EGT)

Ergothioneine is a natural antioxidant known for its powerful ability to protect cells from damage. Found in foods like mushrooms, beans, and grains, Ergothioneine is now widely available as a dietary supplement to support overall health. This unique antioxidant is essential for maintaining healthy skin, promoting cellular protection, and fighting aging. With its role in reducing oxidative stress, it is becoming a key ingredient in supplements and skincare products aimed at anti-aging and wellness.

How Ergothioneine Supports Your Health

  • 1.Cellular Protection and Anti-Aging
  • 2. Support for Mitochondrial Health
  • 3. Brain Health and Neuroprotection
  • 4. Anti-Inflammatory Properties
  • 5. Liver and Organ Protection

Specifications

ItemSpecificationMethod
AppearanceWhite CrystalVisual observation
SmelCharacteristic odorNose smells
Purity>99.9%HPLC
pH (50 mg/mL, 20°C)6.0-7.5pH meter
Melting point (Decompose)270-271°CMelting point detector
Optical rotation[α]D≥(+)122°(c=1,H2O)Polarimeter
Crystallite size100% pass rate for 50 meshSieve
Density0.55-0.75 g/mLBulk density meter
Loss on drying< 0.5%TGA
Total residual solvents (Ethanol)＜200ppmGC
Arsenic≤1.0 ppmICP
Lead≤1.0 ppmICP
Mercury<0.2 ppmICP
Cadmium<0.3 ppmICP
Total heavy metals≤ 10 ppmICP
E.ColiNegative/25gUSP<62>
Staphylococcus aureus RosenbachNegative/25gUSP<62>
P. aeruginosaNegative/25gUSP<62>
SalmonellaNegative/25gUSP<62>
Total coliform<100 CFU/gAOAC
Total yeast and mold count<100 CFU/gUSP<61>
Total viable aerobic count<1000 CFU/gUSP<61>

Package

100G/Bag,500G/Bag,1KG/Bag,25KG/Drum

Storage Condition

Store in well-closed container, at a dry place, protected from light, at a temperature not exceeding 30℃.Use it as soon as possible after unpacking.

Shelf life

2 Years

Nervonic Acid

Nervonic Acid is a fatty acid that plays a critical role in supporting brain health and nerve regeneration. Naturally found in fish oils and seeds, it helps improve memory and learning by promoting the repair of brain cells and the myelin sheath around nerves. As a growing ingredient in brain supplements and pharmaceuticals, Nervonic Acid is essential for cognitive health and is increasingly popular in products aimed at enhancing mental performance and protecting brain function.

How Nervonic Acid Supports Your Health

  1. Supports brain health and cognitive function
  2. Promotes nerve cell regeneration
  3. Important for myelin sheath formation
  4. Enhances learning and memory

Specifications

ItemSpecificationMethod
AppearanceWhite flat-crystalVisual observation
SmelCharacteristic odorNose smells
Nervonic Acid(g/100G)>95%HPLC
Loss on drying<3%TGA
Water<3%TGA
Residual solvent＜10ppmGC
Arsenic≤1.0 ppmICP
Lead≤1.0 ppmICP
Mercury<0.2 ppmICP
Cadmium<0.3 ppmICP
Total heavy metals≤ 10 ppmICP
E.ColiNegative/25gUSP<62>
Staphylococcus aureus RosenbachNegative/25gUSP<62>
P. aeruginosaNegative/25gUSP<62>
SalmonellaNegative/25gUSP<62>
Total coliform<100 CFU/gAOAC
Total yeast and mold count<100 CFU/gUSP<61>
Total viable aerobic count<1000 CFU/gUSP<61>

Package

100G/Bag,500G/Bag,1KG/Bag,25KG/Drum

Storage Condition

Store in well-closed container, at a dry place, protected from light, at a temperature not exceeding 30℃.Use it as soon as possible after unpacking.

Shelf life

2 Years

Ectoine

Ectoine is a natural compound that provides incredible hydration and protection for the skin. Originally discovered in bacteria living in extreme environments, it helps retain moisture and shields the skin from environmental stress like UV rays and pollution. Ectoine is commonly used in skincare products for its ability to soothe sensitive skin, reduce inflammation, and promote skin barrier repair. It is widely accepted in the cosmetics industry for its anti-aging and moisturizing properties.

How Ectoine Your Health

  1. Moisture retention and hydration
  2. Skin barrier protection
  3. Reduces UV-induced damage
  4. Anti-inflammatory properties
  5. Helps prevent skin aging

Specifications

ItemSpecificationMethod
AppearanceWhite PowderVisual observation
SmelCharacteristic odorNose smells
Assay>98%HPLC
Purity(By HPLC,% Area)>99%HPLC
Specific Rotation+139°～+145°Optical rotation method
Loss on drying<2%Oven drying method
Ph6.0~8.0Glass electrode method
Arsenic≤1.0 ppmICP
Lead≤1.0 ppmICP
Mercury<0.2 ppmICP
Cadmium<0.3 ppmICP
Total heavy metals≤ 10 ppmICP
E.ColiNegative/25gUSP<62>
Staphylococcus aureus RosenbachNegative/25gUSP<62>
P. aeruginosaNegative/25gUSP<62>
SalmonellaNegative/25gUSP<62>
Total coliform<100 CFU/gAOAC
Total yeast and mold count<100 CFU/gUSP<61>
Total viable aerobic count<1000 CFU/gUSP<61>

Package

100G/Bag,500G/Bag,1KG/Bag,25KG/Drum

Storage Condition

Store in well-closed container, at a dry place, protected from light, at a temperature not exceeding 30℃.Use it as soon as possible after unpacking.

Shelf life

2 Years

PQQ (Pyrroloquinoline Quinone)

PQQ is a vitamin-like nutrient that supports brain health and energy production at the cellular level. Naturally found in small amounts in foods like kiwi, spinach, and green tea, PQQ helps improve memory, mental clarity, and physical energy by boosting mitochondrial function. Known for its anti-aging and cognitive benefits, PQQ is a powerful ingredient in supplements designed to support overall brain and body vitality, making it a must-have for those looking to enhance mental and physical performance.

How PQQ Supports Your Health

  1. Antioxidative properties
  2. Promotes regeneration of neurons
  3. Enhances mitochondrial function
  4. Supports brain health and cognitive performance
  5. Improves memory and learning

Specifications

ItemSpecificationMethod
AppearanceReddish PowderVisual observation
SmelCharacteristic odorNose smells
Purity>99%HPLC
Water<12TGA
Arsenic≤1.0 ppmICP
Lead≤1.0 ppmICP
Mercury<0.2 ppmICP
Cadmium<0.3 ppmICP
Total heavy metals≤ 10 ppmICP
E.ColiNegative/25gUSP<62>
Staphylococcus aureus RosenbachNegative/25gUSP<62>
P. aeruginosaNegative/25gUSP<62>
SalmonellaNegative/25gUSP<62>
Total coliform<100 CFU/gAOAC
Total yeast and mold count<100 CFU/gUSP<61>
Total viable aerobic count<1000 CFU/gUSP<61>

Package

100G/Bag,500G/Bag,1KG/Bag,25KG/Drum

Storage Condition

Store in well-closed container, at a dry place, protected from light, at a temperature not exceeding 30℃.Use it as soon as possible after unpacking.

Shelf life

2 Years

Real-World Applications for Our Fermented Antioxidants

Santa Biotech’s raw materials are versatile and can be used across various industries to enhance product efficacy and address specific health and beauty concerns:

Dietary Supplements

Incorporate powerful antioxidants like Ergothioneine and PQQ to create high-performance supplements.
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Cosmetics

Add anti-aging properties to skincare products using Ectoine and other natural ingredients.
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Functional Foods

Enhance food products with natural antioxidants that support overall health and longevity.
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Health Products

Formulate health products that focus on cellular health and longevity using our advanced raw materials.
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Pharmaceuticals

Use our ingredients in advanced formulations for treating oxidative stress and supporting cognitive function.
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Beverage

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Science-Proven Results You Can Trust

At Santa Biotech, we believe that science speaks louder than words. Our natural fermentation antioxidants—Ergothioneine, Nervonic Acid, Ectoine, and PQQ—are not just powerful ingredients, but they are backed by solid research and proven results. Here’s a look at the data behind each product:
Ergothioneine: Cellular Protection at Its Best
Ergothioneine Can Reduce Cellular Oxidative Stress By Up To 50%
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Key Data: Studies show Ergothioneine can reduce cellular oxidative stress by up to 50%, improving overall cell longevity and resilience.

Proven Benefits: Ergothioneine is used in functional foods, dietary supplements, and skincare products to enhance cellular health and slow the aging process.

Study Reference: A 2018 study published in the Journal of Antioxidants highlighted its role in reducing oxidative damage and inflammation in skin cells.

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Nervonic Acid Increases Brain Function By Enhancing Nerve Growth Factor By 30%
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Key Data: Clinical research shows that Nervonic Acid increases brain function by enhancing nerve growth factor by 30%, aiding in cognitive clarity and nerve repair.

Proven Benefits: Ideal for supplements targeting brain health and pharmaceutical products focused on neuroprotection.

Study Reference:In 2020, a study in Neuropharmacology found that Nervonic Acid promotes better cognitive performance in aging populations.

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Ectoine has been clinically shown to improve skin hydration by 60% and reduce fine lines by 25% over four weeks.
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Key Data: Ectoine has been clinically shown to improve skin hydration by 60% and reduce fine lines by 25% over four weeks.

Proven Benefits: Commonly used in anti-aging skincare and dermatology products, Ectoine protects the skin from UV damage and environmental stress.

Study Reference:A 2019 clinical trial demonstrated Ectoine’s ability to protect skin cells from pollutants and UV radiation, improving skin texture and hydration.

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PQQ is proven to increase mitochondrial biogenesis by 40%, leading to enhanced cellular energy production and regeneration
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Key Data: Studies show PQQ is proven to increase mitochondrial biogenesis by 40%, leading to enhanced cellular energy production and regeneration

Proven Benefits: Research published in Cell Metabolism in 2021 showed that PQQ improves mitochondrial function and increases energy efficiency at the cellular level.

Study Reference: A 2018 study published in the Journal of Antioxidants highlighted its role in reducing oxidative damage and inflammation in skin cells.

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Formulate with Confidence: Expert Guidelines for Success

Discover how to effectively use our natural fermentation-based raw materials—Ergothioneine, Nervonic Acid, Ectoine, and PQQ—in your formulations. Whether you’re developing dietary supplements, skincare products, or functional foods, these guidelines provide practical data to help you create innovative, high-performing products that meet your market’s needs.
Ergothioneine Formulation Guide

Applications

Dietary Supplements, Cosmetics, Health Products

Suggested Concentration

Dietary Supplements: 5–10 mg/day

Cosmetics: 0.1–0.5% in topical formulations

Ideal Combinations

Combine with Vitamin C and Hyaluronic Acid in cosmetics for enhanced hydration and antioxidation.

Additional Notes

Ergothioneine is a powerful antioxidant that helps protect cells from oxidative stress. It is commonly used in anti-aging products and supplements that support cognitive health.

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Applications

Dietary Supplements, Cosmetics, Health Products

Suggested Concentration

Dietary Supplements: 5–10 mg/day

Cosmetics: 0.1–0.5% in topical formulations

Ideal Combinations

Combine with Vitamin C and Hyaluronic Acid in cosmetics for enhanced hydration and antioxidation.

Additional Notes

Ergothioneine is a powerful antioxidant that helps protect cells from oxidative stress. It is commonly used in anti-aging products and supplements that support cognitive health.

Asking Details

Applications

Dietary Supplements, Cosmetics, Health Products

Suggested Concentration

Dietary Supplements: 5–10 mg/day

Cosmetics: 0.1–0.5% in topical formulations

Ideal Combinations

Combine with Vitamin C and Hyaluronic Acid in cosmetics for enhanced hydration and antioxidation.

Additional Notes

Ergothioneine is a powerful antioxidant that helps protect cells from oxidative stress. It is commonly used in anti-aging products and supplements that support cognitive health.

Asking Details

Applications

Dietary supplements, functional foods

Suggested Concentration

Dietary Supplements: 10–20 mg/day

Functional Foods: 5–10 mg/serving

Ideal Combinations

PQQ works well with Coenzyme Q10 to improve energy production at the cellular level.

Additional Notes

PQQ enhances mitochondrial function, supports energy metabolism, and promotes overall vitality. It’s a critical ingredient in supplements designed for athletic performance and longevity.

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Reliable Supply Chains That Ensure Your Business Runs Smoothly

We understand that consistent supply is essential for your production. Our commitment to stable supply chains includes:
Reliable Partnerships: Working with trusted suppliers and logistics partners to ensure on-time delivery.
Scalable Production: Meeting the needs of both small and large orders with ease.
Global Logistics: Ensuring seamless shipping and tracking for international clients, with guaranteed supply continuity.
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Stay Ahead with Global Regulatory Compliance

Santa Biotech’s raw materials are compliant with international regulatory standards, offering confidence to customers across various regions:
Ergothioneine: Approved by EFSA in the EU and recognized as GRAS by the U.S. FDA
Nervonic Acid: Compliant with China’s NHC standards and accepted in pharmaceuticals in multiple regions.
Ectoine: Approved in the EU and Japan for cosmetic applications.
PQQ: GRAS-certified by the U.S. FDA and authorized for supplements in Japan and the EU.
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Innovative Fermentation Technology

At Santa Biotech, our advanced synthetic biology fermentation technology sets us apart from traditional production methods. We utilize cutting-edge processes that ensure high purity, consistency, and efficiency in producing potent antioxidants Ergothioneine, Nervonic Acid, Ectoine, and PQQ.Key Advantages of Our Fermentation Process:

√ Precision and Consistency: Each batch is produced under controlled conditions, ensuring consistent product quality every time. This reduces variability and ensures that our clients receive the same high standard of product in every order.
√ Environmentally Friendly: Our synthetic biology fermentation process is designed with sustainability in mind. It uses fewer resources, generates less waste, and has a smaller carbon footprint compared to chemical synthesis and other extraction processes.
√ Scalability: Whether you need a small pilot batch or large-scale production, our fermentation technology is scalable to meet the needs of growing businesses, providing flexibility without sacrificing quality. Enhanced Bioavailability: The bioactive compounds produced through our fermentation process are more readily absorbed by the body, increasing the effectiveness of the final product in supplements and cosmetics.
√ By choosing Santa Biotech’s fermentation technology, you’re selecting a partner that prioritizes precision, purity, and sustainability, ensuring your products meet the highest standards.
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Frequently Asked Questions About Our Key Ingredients: Ergothioneine, Nervonic Acid, Ectoine, and PQQ

This FAQ section is designed to address your key concerns, from product efficacy and formulation compatibility to compliance and quality assurance. For further information, please reach out to our team for personalized support and technical guidance.
Our ingredients verified by third-party testing through Eurofins, a well-recognized European testing agency. Each batch undergoes rigorous quality testing to ensure the stated purity levels。
Yes, we comply with both U.S. and European regulations for dietary supplement and cosmetic ingredients. We provide certificates of analysis (COAs) with each order, covering purity, potency, and other quality markers as required.
Santa Biotech follows Good Manufacturing Practices (GMP) and has ISO certifications, ensuring a consistent and high-standard manufacturing process. These certifications are readily available upon request.
Each ingredient batch is tested for contaminants and heavy metals, ensuring that they meet U.S. and European safety limits for dietary supplements.

Ergothioneine is a naturally occurring antioxidant that protects cells from oxidative stress and damage. It is produced using advanced synthetic biology fermentation techniques. Ergothioneine is commonly used in dietary supplements and skincare products for its potent antioxidant properties, supporting cellular health and reducing signs of aging.

Our L-Ergothioneine is produced using cutting-edge fermentation technology, ensuring high purity and stability. It's free from synthetic impurities and toxic solvent residues, making it a safe and effective antioxidant for dietary supplements, cosmetics, and functional foods.
Yes, our Nervonic Acid is derived from a patented fermentation process, ensuring exceptional safety and stability. It is free from harmful additives or preservatives and is extensively tested to meet global safety standards, making it suitable for long-term use in health supplements and skincare products.
Ectoine is a powerful ingredient known for its cell-protecting and hydrating properties. It strengthens the skin barrier, reduces inflammation, and helps combat signs of aging. Our Ectoine is produced using natural fermentation, ensuring it is pure, highly effective, and safe for sensitive skin.

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We Offer Innovative Natural Antioxidants Ergothioneine, Nervonic Acid, Ectoine, PQQ, Driving Innovation In Health And Beauty.
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