Discover PQQ – The Key to Cellular Energy and Brain Health
Explore PQQ: Your Complete Guide
How to Choose High-Quality PQQ for Your Products
Look for These Key Quality Indicators:
- Purity: High-Performance Liquid Chromatography (HPLC) purity of over 98%.
- Water Solubility: PQQ should be highly soluble in water, ensuring easy formulation.
- Stability: PQQ must maintain stability under various conditions, including light, heat, and pH changes.
Purity Standards for PQQ
Production Method Influence Quality and Efficacy
Santa Biotech Nervonic Acid
Why Choose PQQ? The Cellular Energy Booster
Boosts Mitochondrial Function
Enhances Cognitive Performance
Potent Antioxidant Properties
Supports Heart Health
Proven Anti-aging Effects
PQQ Specifications: Key Details
Our PQQ is produced to meet the highest global standards, ensuring it complies with both European and U.S. regulations. It’s ideal for use in dietary supplements and functional foods.
PQQ Specifications
Parameter
| Item | Specification | Method |
|---|---|---|
| Appearance | White Crystal | Visual observation |
| Smel | Characteristic odor | Nose smells |
| Purity | >99.9% | HPLC |
| pH (50 mg/mL, 20°C) | 6.0-7.5 | pH meter |
| Melting point (Decompose) | 270-271°C | Melting point detector |
| Optical rotation | [α]D≥(+)122°(c=1,H2O) | Polarimeter |
| Crystallite size | 100% pass rate for 50 mesh | Sieve |
| Density | 0.55-0.75 g/mL | Bulk density meter |
| Loss on drying | < 0.5% | TGA |
| Total residual solvents (Ethanol) | ＜200ppm | GC |
| Arsenic | ≤1.0 ppm | ICP |
| Lead | ≤1.0 ppm | ICP |
| Mercury | <0.2 ppm | ICP |
| Cadmium | <0.3 ppm | ICP |
| Total heavy metals | ≤ 10 ppm | ICP |
| E.Coli | Negative/25g | USP<62> |
| Staphylococcus aureus Rosenbach | Negative/25g | USP<62> |
| P. aeruginosa | Negative/25g | USP<62> |
| Salmonella | Negative/25g | USP<62> |
| Total coliform | <100 CFU/g | AOAC |
| Total yeast and mold count | <100 CFU/g | USP<61> |
| Total viable aerobic count | <1000 CFU/g | USP<61> |
Package
Storage Condition
Shelf life
Popular Products Around the World Using PQQ
PQQ is revolutionizing health and wellness products globally, powering top brands like Jarrow Formulas and Mikimoto Cosmetics. Its ability to boost energy, enhance brain performance, and protect cells makes it a game-changing ingredient in supplements, functional foods, and skincare, offering consumers cutting-edge solutions for vitality and anti-aging.
How PQQ Improves Your Product’s Performance
Dietary Supplements
Cosmetics
Functional Foods
Pharmaceuticals
How Nervonic Acid Work Synergistically With Other Ingredients?
What Are The Regulations Surrounding Nervonic Acid In Different Regions?
The Science Behind PQQ: Advanced Production Methods
Santa Biotech employs advanced fermentation techniques combined with synthetic biology to produce nervonic acid. This process allows for high yields, purity, and eco-friendly production.
What is the most advanced method for producing high-quality PQQ, and how does it improve product efficacy?
The most advanced method for producing high-quality PQQ is synthetic biology fermentation technology. This process mimics natural microbial production, ensuring higher purity and bioactivity compared to chemical synthesis methods. The fermentation process produces fewer impurities, leading to a more potent and effective product. The result is a PQQ with enhanced efficacy in promoting mitochondrial health, cellular energy, and overall antioxidant capacity.
How does synthetic biology fermentation technology enhance the purity and stability of PQQ compared to traditional methods?
Synthetic biology fermentation technology uses genetically engineered microorganisms to produce PQQ in a controlled environment. This method results in fewer byproducts and impurities than traditional chemical synthesis. Fermentation also ensures a higher degree of stability because the process can be optimized for consistent quality. As a result, PQQ produced through fermentation has superior purity, stability, and is free from harmful chemical residues, making it a better option for supplements, functional foods, and skincare products.
What are the environmental and economic advantages of using advanced fermentation technology for PQQ production?
Fermentation technology is more eco-friendly compared to chemical synthesis. It uses renewable resources like sugars and plant-based feedstocks, reducing reliance on harmful chemicals and fossil fuels. The process generates less toxic waste, leading to fewer environmental pollutants. Economically, fermentation can lower production costs over time as the process becomes more efficient and scalable, resulting in lower manufacturing costs for high-purity PQQ and making it more accessible for large-scale production.
How does the production method influence the bioavailability and potency of PQQ in end products?
The production method significantly impacts the bioavailability and potency of PQQ. PQQ produced through fermentation has a more stable molecular structure, which enhances its absorption in the body. This method also results in higher purity, meaning the PQQ is more potent, requiring smaller doses to achieve desired health benefits. Better bioavailability ensures that PQQ can be absorbed efficiently, maximizing its impact on cellular energy, brain function, and antioxidant protection.
What quality control measures are involved in advanced PQQ production to ensure consistent product quality?
Advanced PQQ production using fermentation technology involves strict quality control measures at every stage. This includes:
- Sterilization of production equipment to avoid contamination.
- Real-time monitoring of fermentation conditions such as temperature, pH, and nutrient supply to ensure optimal microbial growth.
- Post-production testing, including HPLC (High-Performance Liquid Chromatography), to verify the purity and potency of the final product.
- Third-party testing for heavy metals, residual solvents, and microbiological contaminants to ensure product safety.
Are there any emerging technologies or innovations that are expected to further improve PQQ production?
Emerging technologies such as CRISPR-based gene editing and bioprocess optimization are expected to further enhance PQQ production. CRISPR allows for more precise engineering of microbial strains to improve yield and efficiency. Advances in bioprocess automation and AI-driven fermentation control can optimize production conditions in real time, increasing both output and quality. Additionally, green chemistry innovations are making the fermentation process even more sustainable by minimizing waste and energy usage.
How does the choice of production method impact the regulatory approval process in different regions?
The production method plays a critical role in obtaining regulatory approval. PQQ produced through natural fermentation is often viewed more favorably by regulatory bodies because it’s considered a natural or bioidentical product. In the U.S., fermentation-based PQQ can be classified as a GRAS (Generally Recognized as Safe) substance, streamlining approval for use in supplements. In the EU, fermentation-produced PQQ may more easily pass novel food regulations because of its cleaner profile compared to synthetic alternatives. Japan also favors naturally-derived ingredients for use in functional foods and health supplements, making fermentation-based PQQ more likely to be approved in these regions.
PQQ Regulations: Global Approvals and Standards
Global Regulatory Overview for PQQ
1. United States
Regulation: PQQ is classified under GRAS (Generally Recognized as Safe) status by the FDA.
Regulation Number: GRN No. 635 (FDA GRAS Notification for PQQ Disodium Salt)
Scope: Approved for use in dietary supplements, functional foods, and beverages.
2. European Union
Regulation: PQQ is classified as a novel food under EU Regulation (EU) No 2015/2283.
Scope: Requires pre-approval for its use in food products across the EU.
3. Japan
Regulation: PQQ is approved under the Food for Specified Health Uses (FOSHU) by the Ministry of Health, Labour and Welfare (MHLW).
Scope: Widely used in functional foods and health supplements.
4. China
Regulation: PQQ is regulated as a new resource food under Food Safety Law of the People’s Republic of China and managed by the National Health Commission (NHC).
Regulation Number:GB standards under GB 16740-2014 for health supplements.
Scope: Commonly used in health and dietary supplements.
5. Other Regions
Australia: Regulated by the Therapeutic Goods Administration (TGA) under the Therapeutic Goods Act 1989 for supplement use.
Canada: PQQ is regulated as a natural health product under Health Canada’s Natural Health Products Directorate (NHPD).
Regulation Number: Subject to Canada’s Natural Health Product Regulations (SOR/2003-196).
By adhering to these global regulations, Santa Biotech ensures the safety, quality, and compliance of its PQQ products in various markets worldwide.
Formulating with PQQ: Best Practices for Maximum Benefits
Pairing with Synergistic Ingredients
Recommended Usage:
1.Dietary Supplements
- Recommended Daily Dose: 10 mg to 20 mg per day.
- Target Benefits: Mitochondrial support, enhanced energy levels, and cognitive health.
- Usage Guidance: Often combined with CoQ10 or other antioxidants for improved efficacy.
2.Functional Foods and Beverages
- Dosage Range: Typically 5 mg to 10 mg per serving.
- Target Benefits: Energy boost, anti-aging, and overall wellness.
- Usage Guidance: Suitable for powder formulations or functional drinks that promote daily vitality.
3.Cosmetics and Skincare
- Recommended Concentration: 0.1% to 0.3% in serums and creams.
- Target Benefits: Anti-aging effects, antioxidant protection, and skin rejuvenation.
- Usage Guidance: Best used in combination with other antioxidants like Vitamin C for enhanced skin health.
Ensuring Quality: Santa Biotech’s PQQ Standards
Certified Quality, Trusted by Global Brands
Every batch of PQQ produced by Santa Biotech undergoes rigorous testing to ensure the highest standards of quality and consistency.
Our Quality Assurance Includes:
- ISO22000 Certificated
- Comprehensive Batch Testing for Purity and Potency
- Certificates of Analysis (COA) Provided with Every Shipment
- Transparent Supply Chain for Reliable Sourcing
